Detail
| LncRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC, TncRNA, MENepsilon/beta |
| Region | GRCh38_11:65422774-65445540 Sequence |
| Ensembl | ENSG00000245532 |
| RefSeq | NR_028272 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Western blot etc. |
| Sample | nasopharyngeal carcinoma tissues, cell lines (HK-1, CNE-1, CNE-2 subclone S18 and SUNE1) |
| Expression Pattern | down-regulated |
| Function Description | NEAT1 was upregulated and let-7a-5p was downregulated in NPC tissues,as well as NPC cell lines.Inhibition of NEAT1 markedly repressed the cisplatin resistance of NPC cells. NEAT1 was demonstrated to interact with let-7a-5p. Besides, a negative correlation between NEAT1 and let-7a-5p expression was observed in NPC tissues.Rsf-1 was confirmed as a target of let-7a-5p.NEAT1 remarkably reversed the inhibitory effect of let-7q-5p on the cisplatin resistance of NPC cells in vitro. Additionally, NEAT1 knockdown inhibited the Ras-MAPK pathway in NPC cells.NEAT1 knockdown suppressed tumor growth in the presence of cisplatin in vivo.Overall,these findings suggest that NEAT1/let-7a-5p axis regulates the cisplatin resistance in NPC by targeting Rsf-1 and modulating the Ras-MAPK signaling pathway. |
| Pubmed ID | 29565706 |
| Year | 2018 |
| Title | LncRNA NEAT1/let-7a-5p axis regulates the cisplatin resistance in nasopharyngeal carcinoma by targeting Rsf-1 and modulating the Ras-MAPK pathway. |
| External Links |
| Links for NEAT1 | GenBank HGNC lncrnadb Noncode |
| Links for nasopharyngeal cancer | Omim Cosmic |
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