Detail
| LncRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC, TncRNA, MENepsilon/beta |
| Region | GRCh38_11:65422774-65445540 Sequence |
| Ensembl | ENSG00000245532 |
| RefSeq | NR_028272 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Western blot etc. |
| Sample | NPC tissues, cell lines (5-8F, CNE1, CNE2, S26, HNE1, SUNE1, HONE1, NP69) |
| Expression Pattern | down-regulated |
| Function Description | NEAT1 is down-regulated in NPC tissues and is associated with poor prognosis. NEAT1 antagonized miR-101-3p through a competing endogenous RNA (ceRNA) mechanism and that the interaction between NEAT1 and EMP2 was miR-101-3p dependent. a novel connection of NEAT1, miR-101-3p and EMP2 in NPC migration and radiation resistance. NPC patients with high NEAT1 expression levels had longer overall survival than patients with low and negative NEAT1 expression levels. |
| Pubmed ID | 29050268 |
| Year | 2017 |
| Title | Long non-coding RNA NEAT1 regulates epithelial membrane protein 2 expression to repress nasopharyngeal carcinoma migration and irradiation-resistance through miR-101-3p as a competing endogenous RNA mechanism. |
| External Links |
| Links for NEAT1 | GenBank HGNC lncrnadb Noncode |
| Links for nasopharyngeal cancer | Omim Cosmic |
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