Detail
| LncRNA Name | NEAT1 |
| Synonyms | NEAT1, LINC00084, NCRNA00084, TncRNA, VINC, TncRNA, MENepsilon/beta |
| Region | GRCh38_11:65422774-65445540 Sequence |
| Ensembl | ENSG00000245532 |
| RefSeq | NR_028272 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, luciferase assay etc. |
| Sample | Two human breast cancer cell lines (MCF-7 , SK-BR-3), breast cancer tissues |
| Expression Pattern | down-regulated |
| Function Description | NEAT1 expression was significantly up-regulated in breast cancer tissues compared to adjacent normal tissues, and higher NEAT1 was positively associated with lymph node metastasis and TNM stage. Patients with higher NEAT1 had a poor prognosis. In addition, NEAT1 promoted cell invasion and proliferation by negatively regulating miR-218 in breast cancer.MiR-218 is a direct target of NEAT1. Kaplan-Meier analysis and the log-rank test were used to establish the relationship between NEAT1 and overall survival. Recent studies have shown that lncRNAs play a crucial effect in multiple processes in cells by acting as competing endogenous (ceRNAs) to regulate miRNAs. |
| Pubmed ID | 28946559 |
| Year | 2017 |
| Title | NEAT1 negatively regulates miR-218 expression and promotes breast cancer progression. |
| External Links |
| Links for NEAT1 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.