Detail
| LncRNA Name | NKILA |
| Synonyms | AK056098 |
| Region | GRCh38_20:57710183-57712780 Sequence |
| Ensembl | ENSG00000278709 |
| RefSeq | NR_131157 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi, RIP etc. |
| Sample | breast cancer tissues |
| Expression Pattern | down-regulated |
| Function Description | Importantly, NKILA is essential to prevent over-activation of NF-î?«B pathway in inflammation-stimulated breast epithelial cells. Furthermore, low NKILA expression is associated with breast cancer metastasis and poor patient prognosis. Therefore, lncRNAs can directly interact with functional domains of signaling proteins, serving as a class of NF-î?«B modulators to suppress cancer metastasis. |
| Pubmed ID | 25759022 |
| Year | 2015 |
| Title | A Cytoplasmic NF-î?«B Interacting Long Noncoding RNA Blocks Iî?«B Phosphorylation and Suppresses Breast Cancer Metastasis. |
| External Links |
| Links for NKILA | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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