Detail
| LncRNA Name | NNT-AS1 |
| Synonyms | NA |
| Region | GRCh38_5:43571594-43603230 Sequence |
| Ensembl | ENSG00000248092 |
| RefSeq | NR_073113 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C50 |
| Methods | RT-PCR, Western blot analysis, Luciferase reporter assay, RIP, RNA pull-down assay |
| Sample | GC cell lines (SGC-7901, BGC-823, MGC-803 and MKN-45) Normal gastric mucosa cell line GES-1, the tumour tissue and adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | NNT-AS1 expression level was significantly up-regulated in GC tissue and cell lines compared with adjacent normal tissue and normal cell lines.NNT-AS1 knockdown suppressed the proliferation and invasion ability and induced the GC cell cycle progression arrest at G0/G1 phase. miR-424 targeted the 3'-UTR of NNT-AS1.the molecular binding within NNT-AS1 and miR-424, therefore jointly forming the RNA-induced silencing complex (RISC). Moreover, E2F1 was verified to act as the target gene of NNT-AS1/miR-424, indicating the NNT-AS1/miR-424/E2F1 axis. |
| Pubmed ID | 30006956 |
| Year | 2018 |
| Title | Long non-coding RNA NNT-AS1 sponges miR-424/E2F1 to promote the tumorigenesis and cell cycle progression of gastric cancer. |
| External Links |
| Links for NNT-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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