Detail
| LncRNA Name | NORAD |
| Synonyms | NORAD, LINC00657, ASHGA5P032173 |
| Region | GRCh38_20:36045622-36050960 Sequence |
| Ensembl | ENSG00000260032 |
| RefSeq | NR_027451 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR, Western blot, in vitro knockdown, Luciferase reporter assay |
| Sample | Human CRC cancer cell lines (SW480 and HCT116) |
| Expression Pattern | up-regulated |
| Function Description | NORAD served as a competing endogenous RNA for miR-202-5p.We found that there was an inversely relationship between the expression of NORAD and miR-202-5p in CRC tissues.Moreover, overexpression of miR-202-5p in SW480 and HCT116 cells significantly inhibited cellular proliferation,migration and invasion.Taken together,our study demonstrated NORAD/miR-202-5p axis plays a pivot function on CRC progression. |
| Pubmed ID | 29471886 |
| Year | 2018 |
| Title | LncRNA NORAD contributes to colorectal cancer progression by inhibition of miR-202-5p. |
| External Links |
| Links for NORAD | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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