Detail
| LncRNA Name | BANCR |
| Synonyms | BANCR, LINC00586 |
| Region | GRCh38_9:69296682-69311111 Sequence |
| Ensembl | ENSG00000278910 |
| RefSeq | NR_047671 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | melanoma |
| ICD-0-3 | M8720/3 |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | melanoma tissues, cells lines (A375, A875 and M14, and human epidermal melanocytes) |
| Expression Pattern | up-regulated |
| Function Description | the expression of the BANCR was low in melanocytic nevus and human melanocytes but high in melanoma tissues and cell lines. Knockdown of BANCR inhibited melanoma cell proliferation and invasion, and induced cell apoptosis.the inhibitory effect of BANCR siRNA in cell growth and migration.miR-204 was a direct target of BANCR and neurogenic locus notch homolog protein 2 (Notch2) was a direct target of miR-204. BANCR may promote melanoma cell growth through inhibition of miR-204, leading to the activation of Notch2 pathway. BANCR knockdown inhibited tumor growth in vivo. |
| Pubmed ID | 29075789 |
| Year | 2017 |
| Title | BANCR contributes to the growth and invasion of melanoma by functioning as a competing endogenous RNA to upregulate Notch2 expression by sponging miR-204. |
| External Links |
| Links for BANCR | GenBank HGNC lncrnadb Noncode |
| Links for melanoma | Omim Cosmic |
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