Detail
| LncRNA Name | OIP5-AS1 |
| Synonyms | OIP5-AS1, cyrano, linc-OIP5 |
| Region | GRCh38_15:41283990-41309737 Sequence |
| Ensembl | ENSG00000247556 |
| RefSeq | NR_026757 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatoblastoma |
| ICD-0-3 | C22.0 M8970/3 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | hepatoblastoma tissues, cell lines (HepG2, HuH-6, SMMC-7721, QSG-7701 and L-02) |
| Expression Pattern | up-regulated |
| Function Description | OIP5-AS1 was oncogenic in hepatoblastoma for the high expression of it in hepatoblastoma tissues and cells. OIP5-AS1 knockdown was carried out in cancer cells.Unsurprisingly,this action was verified to be able to inhibit cell proliferation, metastasis and EMT progress in hepatoblastoma.We discovered OIP5-AS1 is located in nucleus of cancerous cells.It could target to miR-186a-5p and up-regulate the target gene of miR-186a-5p (ZEB1).Based on all above findings,we came into a conclusion that OIP5-AS1 is a ceRNA in Hepatoblastoma cells through modulating miR-186a-5p/ZEB1. |
| Pubmed ID | 29475118 |
| Year | 2018 |
| Title | Kockdown of OIP5-AS1 expression inhibits proliferation, metastasis and EMT progress in hepatoblastoma cells through up-regulating miR-186a-5p and down-regulating ZEB1. |
| External Links |
| Links for OIP5-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for hepatoblastoma | Omim Cosmic |
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