Detail
| LncRNA Name | OIP5-AS1 |
| Synonyms | OIP5-AS1, cyrano, linc-OIP5 |
| Region | GRCh38_15:41283990-41309737 Sequence |
| Ensembl | ENSG00000247556 |
| RefSeq | NR_026757 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | oral cancer |
| ICD-0-3 | C06.9 |
| Methods | RNA-seq, Microarray, qPCR, Luciferase reporter assay, RIP etc. |
| Sample | oral tumor tissues, cell lines (FANTOM 5 and GTEx) |
| Expression Pattern | up-regulated |
| Function Description | Expression analysis showed downregulation of miRNAs and upregulation of downstream target genes, particularly in undifferentiated tumors with high-level of OIP5-AS1 suggesting OIP5-AS1 could post-transcriptionally modulate the downstream target genes. Further, systematic epigenomic analysis of OIP5-AS1 promoter revealed binding motifs for MYC, NANOG and KLF4 suggesting that OIP5-AS1 could be transactivated by stemness-associated transcription factors in cancer. OIP5-AS1 overexpression in undifferentiated oral tumors may be suggestive of enhanced cancer stemness, and consequently, poor clinical outcome. |
| Pubmed ID | 29728583 |
| Year | 2018 |
| Title | LncRNA OIP5-AS1 is overexpressed in undifferentiated oral tumors and integrated analysis identifies as a downstream effector of stemness-associated transcription factors. |
| External Links |
| Links for OIP5-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for oral cancer | Omim Cosmic |
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