Detail
| LncRNA Name | OIP5-AS1 |
| Synonyms | OIP5-AS1, cyrano, linc-OIP5 |
| Region | GRCh38_15:41283990-41309737 Sequence |
| Ensembl | ENSG00000247556 |
| RefSeq | NR_026757 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Microarray, qPCR, Western blot etc. |
| Sample | colorectal cancer tissues, cell line (LoVo, SW480 and HEK293T) |
| Expression Pattern | down-regulated |
| Function Description | LncRNA OIP5-AS1 and DYRK1A were down-regulated in radio-resistant CRC cell lines. OIP5-AS1 suppressed the expression of miR-369-3p, thus up-regulating DYRK1A, the downstream gene of miR-369-3p. OIP5-AS1 and DYRK1A impaired cell clonogenic survival and promoted cell apoptosis after irradiation, improving radiosensitivity of CRC cells. Low expression of OIP5-AS1 and DYRK1A was correlated with a poor survival. |
| Pubmed ID | 29773344 |
| Year | 2018 |
| Title | LncRNA OIP5-AS1 regulates radioresistance by targeting DYRK1A through miR-369-3p in colorectal cancer cells. |
| External Links |
| Links for OIP5-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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