Detail
| LncRNA Name | OTUB1-isoform2 |
| Synonyms | OTUB1, HSPC263, OTB1, OTU1 |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Cell proliferation assay, Cell invasion assay etc. |
| Sample | gastric cancer tissues, cell lines (AGS, MGC-803, MKN45, NCI-N87 and HGC-27) |
| Expression Pattern | up-regulated |
| Function Description | The OTUB1-isoform 2 expression levels were higher in the gastric cancer samples than in the paratumorous gland samples. OTUB1-isoform 2 expression levels tightly correlated with tumor size, lymph node metastasis and TNM staging. Higher OTUB1-isoform 2 expression levels led to significantly poorer OS and DFS rates, and a multivariate analysis revealed that OTUB1-isoform 2 was an independent risk factor for DFS. Ectopic overexpression of OTUB1-isoform 2 in gastric cancer cells stimulated proliferation by inducing G1-S transition, suppression of cell apoptosis and promotion of tumor cell invasion and migration. |
| Pubmed ID | 27019636 |
| Year | 2016 |
| Title | Upregulation of the Non-Coding RNA OTUB1-isoform 2 Contributes to Gastric Cancer Cell Proliferation and Invasion and Predicts Poor Gastric Cancer Prognosis. |
| External Links |
| Links for OTUB1-isoform2 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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