Detail
| LncRNA Name | P2RX7-V3 |
| Synonyms | P2RX7 |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | uveal melanoma |
| ICD-0-3 | C69.9 M8720/3 |
| Methods | microarray, qPCR, RNAi etc. |
| Sample | cell lines (MUM2B, OM431, and 293T) |
| Expression Pattern | up-regulated |
| Function Description | Here, we identified a transcriptional variant transcribed from the P2RX7 gene locus, named P2RX7-V3 (P2RX7 variant 3), which was expressed at a high level in UM cells. P2RX7-V3 silencing revealed that this variant acts as a necessary UM oncoRNA. Knockdown of P2RX7-V3 expression significantly suppressed tumor growth in vitro and in vivo. |
| Pubmed ID | 27468714 |
| Year | 2016 |
| Title | P2RX7-V3 is a novel oncogene that promotes tumorigenesis in uveal melanoma. |
| External Links |
| Links for P2RX7-V3 | GenBank HGNC lncrnadb Noncode |
| Links for uveal melanoma | Omim Cosmic |
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