Detail
| LncRNA Name | PAGBC |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gallbladder cancer |
| ICD-0-3 | C23.9 |
| Methods | qPCR, microarray, Western blot, Luciferase reporter assay, RIP etc. |
| Sample | cell lines (GBC-SD, SGC-996, NOZ, EH-GB) |
| Expression Pattern | down-regulated |
| Function Description | In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosisassociated gallbladder cancer lncRNA (lncRNA-PAGBC), which we find to be an independent prognostic marker in GBC. Functional analysis indicates that lncRNA-PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA-PAGBC competitively binds to the tumour suppressive microRNAs miR-133b and miR-511. This competitive role of lncRNA-PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. |
| Pubmed ID | 28887321 |
| Year | 2017 |
| Title | LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis |
| External Links |
| Links for PAGBC | GenBank HGNC lncrnadb Noncode |
| Links for gallbladder cancer | Omim Cosmic |
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