Detail
| LncRNA Name | pancEts-1 |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | neuroblastoma |
| ICD-0-3 | M9500/3 |
| Methods | RNA-seq,qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP etc. |
| Sample | cell lines (NB-1643, SK-N-BE(2), NB-1691, IMR32, BE(2)-CSK-N-AS, SH-SY5Y, and SK-N-SH), NB tissues |
| Expression Pattern | up-regulated |
| Function Description | LncRNA pancEts-1 promoted the growth, invasion, and metastasis of neuroblastoma cells in vitro and in vivo Mechanistically, pancEts-1 bound to hnRNPK to facilitate its physical interaction with B-catenin, whereas hnRNPK stabilized the B-catenin by inhibiting proteasome-mediated degradation, resulting in transcriptional alteration of target genes associated with neuroblastoma progression. Both pancEts-1 and hnRNPK were upregulated in clinical neuroblastoma tissues, and were associated with unfavorable outcome of patients. |
| Pubmed ID | 29311158 |
| Year | 2018 |
| Title | Long Noncoding RNA pancEts-1 Promotes Neuroblastoma Progression through hnRNPK-Mediated B-Catenin Stabilization. |
| External Links |
| Links for pancEts-1 | GenBank HGNC lncrnadb Noncode |
| Links for neuroblastoma | Omim Cosmic |
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