Detail
| LncRNA Name | PANDAR |
| Synonyms | PANDAR, PANDA |
| Region | GRCh38_6:36673621-36675126 Sequence |
| Ensembl | ENSG00000281450 |
| RefSeq | NR_109836 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, RIP, ChIP, Luciferase reporter assay etc. |
| Sample | cell lines (BT474, SK-BR3, MCF-7, T47D and MDA-MB-231) |
| Expression Pattern | up-regulated |
| Function Description | we investigated the role of lncRNA PANDAR in the progression of breast cancer and found that PANDAR was up-regulated in breast cancer tissues and cell lines. The knockdown of PANDAR suppresses G1/S transition of breast cancer cells. We demonstrated mechanistically that the regulation of G1/S transition by PANDAR was partly due to the transcriptional modulation of p16INK4A. Moreover, we showed that PANDAR impacted p16INK4A expression by regulating the recruitment Bmi1 to p16INK4A promoter |
| Pubmed ID | 26927017 |
| Year | 2016 |
| Title | LncRNA PANDAR regulates the G1/S transition of breast cancer cells by suppressing p16(INK4A) expression |
| External Links |
| Links for PANDAR | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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