Detail
| LncRNA Name | PANDAR |
| Synonyms | PANDAR, PANDA |
| Region | GRCh38_6:36673621-36675126 Sequence |
| Ensembl | ENSG00000281450 |
| RefSeq | NR_109836 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, RNAi, Flow cytometry assay etc. |
| Sample | bladder cancer tissues, cell lines (5637, SW780, UMUC3, T24 and SV-HUC-1 etc.) |
| Expression Pattern | up-regulated |
| Function Description | We found that PANDAR was significantly up-regulated in bladder cancer tissues compared with paired-adjacent nontumorous tissues in a cohort of 55 bladder cancer patients. Moreover, increased PANDAR expression was positively correlated with higher histological grade and advanced TNM stage. Further experiments demonstrated that inhibited cell proliferation/migration and induced apoptosis by silencing PANDAR were also observed in bladder cancer cells. Furthermore, over expression of PANDAR in bladder cancer cells promoted the proliferation/migration and suppressed apoptosis. |
| Pubmed ID | 27206339 |
| Year | 2016 |
| Title | Up-regulation of long non-coding RNA PANDAR is associated with poor prognosis and promotes tumorigenesis in bladder cancer. |
| External Links |
| Links for PANDAR | GenBank HGNC lncrnadb Noncode |
| Links for bladder cancer | Omim Cosmic |
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