Detail
| LncRNA Name | PCAT-1 |
| Synonyms | LPCAT1, AGPAT10, AGPAT9, AYTL2, LPCAT-1, PFAAP3, lpcat, lysoPAFAT, PCAT-1, PCA1 |
| Region | GRCh38_8:126556323-127419050 Sequence |
| Ensembl | ENSG00000253438 |
| RefSeq | NR_045262 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | osteosarcoma |
| ICD-0-3 | M9180/3 |
| Methods | qPCR, Western blot, in vitro knockdown, RIP |
| Sample | OS tumor tissues, human OS cell lines (Saos-2, U2OS, MG-63 and 143B) |
| Expression Pattern | up-regulated |
| Function Description | PCAT-1 expression was also upregulated in OS tissues,PCAT-1 could interact with EZH2, thereby repressing p21 expression. Additionally, rescue experiments indicated that PCAT-1 functioned as an oncogene partly via suppressing p21 in OS cells. |
| Pubmed ID | 29291409 |
| Year | 2017 |
| Title | Long noncoding RNA PCAT-1 acts as an oncogene in osteosarcoma by reducing p21 levels. |
| External Links |
| Links for PCAT-1 | GenBank HGNC lncrnadb Noncode |
| Links for osteosarcoma | Omim Cosmic |
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