Detail
| LncRNA Name | PCGEM1 |
| Synonyms | PCGEM1, LINC00071, NCRNA00071, PCAT9 |
| Region | GRCh38_2:192749845-192776899 Sequence |
| Ensembl | ENSG00000227418 |
| RefSeq | NR_002769 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, RNAi, Western blot, ChIP, Luciferase reporter assay, MTT assay etc. |
| Sample | cell lines (LNCaP and CWR22Rv1) |
| Expression Pattern | up-regulated |
| Function Description | We show transcriptional regulation of PCGEM1 in response to androgen deprivation by p54/nrb. While ectopic expression of p54/nrb increases, suppression of p54/nrb by RNAi or knockout (KO) reduces PCGEM1. Moreover, rescue experiments indicate that re-expression of p54/nrb in KO cells restores the ability to induce PCGEM1, leading to upregulation of the androgen receptor splice variant AR3 which has been shown to play a role in castration resistance. |
| Pubmed ID | 27682980 |
| Year | 2016 |
| Title | Regulation of PCGEM1 by p54/nrb in prostate cancer. |
| External Links |
| Links for PCGEM1 | GenBank HGNC lncrnadb Noncode |
| Links for prostate cancer | Omim Cosmic |
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