Detail
| LncRNA Name | PCGEM1 |
| Synonyms | PCGEM1, LINC00071, NCRNA00071, PCAT9 |
| Region | GRCh38_2:192749845-192776899 Sequence |
| Ensembl | ENSG00000227418 |
| RefSeq | NR_002769 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR etc. |
| Sample | cell line (LNCaP) |
| Expression Pattern | up-regulated |
| Function Description | Here, we report a novel function of PCGEM1 that provides growth advantages for prostate cancer cells by regulating tumor metabolism via c-Myc activation. PCGEM1 binds directly to target promoters, physically interacts with c-Myc, promotes chromatin recruitment of c-Myc, and enhances its transactivation activity. We also identified a c-Myc binding domain on PCGEM1 that contributes to the PCGEM1-dependent c-Myc activation and target induction. |
| Pubmed ID | 25512540 |
| Year | 2014 |
| Title | A long noncoding RNA connects c-Myc to tumor metabolism. |
| External Links |
| Links for PCGEM1 | GenBank HGNC lncrnadb Noncode |
| Links for prostate cancer | Omim Cosmic |
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