Detail
| LncRNA Name | PEG10 |
| Synonyms | PEG10, EDR, HB-1, MEF3L, 2-Mar, Mart2, RGAG3, RTL2, SIRH1 |
| Region | GRCh38_7:94656325-94669695 Sequence |
| Ensembl | ENSG00000242265 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hypopharyngeal squamous cell carcinoma |
| ICD-0-3 | C13 M8070/3 |
| Methods | qPCR |
| Sample | tumor tissue and para-carcinoma tissue, HSCC FaDu cell line. |
| Expression Pattern | up-regulated |
| Function Description | In the in vitro experimental studies, enhanced expression of lncRNA PEG10 was significantly associated with increased proliferation, invasion and metastasis of FaDu cells. lncRNA PEG10 was upregulated in HSCC, and its overexpression in HSCC cells promoted an increase in the tumorigenic activities of proliferation, invasion and migration.A total of >75% of patients with HSCC have an advanced stage of the disease at the time of diagnosis (2), and the prognosis of these patients is poor with a 5-year overall survival rate of 30â??35% (3â??5). |
| Pubmed ID | 28928830 |
| Year | 2017 |
| Title | Overexpression of long noncoding RNA PEG10 promotes proliferation, invasion and metastasis of hypopharyngeal squamous cell carcinoma. |
| External Links |
| Links for PEG10 | GenBank HGNC lncrnadb Noncode |
| Links for hypopharyngeal squamous cell carcinoma | Omim Cosmic |
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