Detail
LncRNA Name | PICART1 |
Synonyms | RP11-1094H24.4, PICART1 |
Region | NA Sequence |
Ensembl | NA |
RefSeq | NA |
Circulating | ✘ |
Drug-resisitant | ✘ |
Prognostic | ✘ |
MiRNA | ✘ |
Variant | ✘ |
TF | ✘ |
Methylation | ✘ |
Cancer Name | colorectal cancer |
ICD-0-3 | C19.9 |
Methods | qPCR, Cell transfection, Western blot, Cell proliferation assay etc. |
Sample | CRC tissues, cell line (HCT116) |
Expression Pattern | down-regulated |
Function Description | In breast and colorectal cancer cells and tissues, PICART1 expression was found to be decreased. Ectopic expression of PICART1 suppressed the growth, proliferation, migration, and invasion of MCF7, MDA-MB-231 and HCT116 cells whereas silencing of PICART1 stimulated cell growth and migration. In these cells, the expression of PICART1 suppressed levels of p-AKT (Thr308 and Ser473) and p-GSK3B (Ser9), and accordingly, B-catenin, cyclin D1 and c-Myc expression were decreased, while p21Waf/cip1 expression was increased. |
Pubmed ID | 28339031 |
Year | 2017 |
Title | p53-inducible long non-coding RNA PICART1 mediates cancer cell proliferation and migration. |
External Links |
Links for PICART1 | GenBank HGNC lncrnadb Noncode |
Links for colorectal cancer | Omim Cosmic |
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