Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name PICART1
   Synonyms RP11-1094H24.4, PICART1
   Region NA    Sequence
   Ensembl NA
   RefSeq NA
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name colorectal cancer
   ICD-0-3 C19.9  
   Methods qPCR, Cell transfection, Western blot, Cell proliferation assay etc.
   Sample CRC tissues, cell line (HCT116)
   Expression Pattern down-regulated
   Function Description

In breast and colorectal cancer cells and tissues, PICART1 expression was found to be decreased. Ectopic expression of PICART1 suppressed the growth, proliferation, migration, and invasion of MCF7, MDA-MB-231 and HCT116 cells whereas silencing of PICART1 stimulated cell growth and migration. In these cells, the expression of PICART1 suppressed levels of p-AKT (Thr308 and Ser473) and p-GSK3B (Ser9), and accordingly, B-catenin, cyclin D1 and c-Myc expression were decreased, while p21Waf/cip1 expression was increased.

   Pubmed ID 28339031
   Year 2017
   Title p53-inducible long non-coding RNA PICART1 mediates cancer cell proliferation and migration.
   External Links
   Links for  PICART1 GenBank       HGNC       lncrnadb       Noncode
   Links for  colorectal cancer Omim       Cosmic

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