Detail
| LncRNA Name | PlncRNA-1 |
| Synonyms | CBR3-AS1, PlncRNA-1, PlncRNA1 |
| Region | GRCh38_21:36131767-36175815 Sequence |
| Ensembl | ENSG00000236830 |
| RefSeq | NR_038892 |
| Circulating | ✔ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot etc. |
| Sample | cell line (MCF-7,MDA-MB-468), breast cancer |
| Expression Pattern | down-regulated |
| Function Description | Expression levels of PlncRNA-1 were significantly lower in tumor tissues than those in adjacent healthy tissues. Significantly lower expression levels of PlncRNA-1 were also found in breast cancer patients than those in healthy controls in both breast tissue and serum. Upregulation of PlncRNA-1 promoted the expression of TGF-B1, but inhibited the expression of PHGDH. LncRNA PlncRNA-1 overexpression reduced the proliferation rate, but increased the apoptosis rate of breast cancer cells, while treatment with TGF-B inhibitor reduced those effects of PlncRNA-1 overexpression. |
| Pubmed ID | 29626321 |
| Year | 2018 |
| Title | LncRNA PlncRNA-1 overexpression inhibits the growth of breast cancer by upregulating TGF-B1 and downregulating PHGDH. |
| External Links |
| Links for PlncRNA-1 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.