Detail
| LncRNA Name | PlncRNA-1 |
| Synonyms | CBR3-AS1, PlncRNA-1, PlncRNA1 |
| Region | GRCh38_21:36131767-36175815 Sequence |
| Ensembl | ENSG00000236830 |
| RefSeq | NR_038892 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, in vitro knockdown etc. |
| Sample | CRC tissues, cell lines (SW480, DLD-1, HCT116, SW620, HcoEpiC) |
| Expression Pattern | up-regulated |
| Function Description | High PlncRNA-1 expression was associated with depth of invasion, lymph node metastasis, and TNM stage of CRC patients. Kaplan-Meier curve analysis showed that patients with high PlncRNA-1 expression had a poor overall survival.PlncRNA-1 exerted its effects by targeting the PI3K/Akt signaling pathway in CRC. |
| Pubmed ID | 28835319 |
| Year | 2017 |
| Title | Long Noncoding RNA PlncRNA-1 Promotes Colorectal Cancer Cell Progression by Regulating the PI3K/Akt Signaling Pathway. |
| External Links |
| Links for PlncRNA-1 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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