Detail
| LncRNA Name | PlncRNA-1 |
| Synonyms | CBR3-AS1, PlncRNA-1, PlncRNA1 |
| Region | GRCh38_21:36131767-36175815 Sequence |
| Ensembl | ENSG00000236830 |
| RefSeq | NR_038892 |
| Circulating | ✔ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Western blot, Northern blot, RIP, ChIP, Flow cytometry assay etc. |
| Sample | prostate cancer tissues, cell lines (22RV1, LNCaP, PC3, DU145) |
| Expression Pattern | up-regulated |
| Function Description | In this study, we demonstrated that long non-coding RNA PlncRNA-1, whose expression is promoted by Androgen Receptor (AR), protects AR from microRNA-mediated suppression in PCa cells. PlncRNA-1 knockdown resulted in the up-regulation of a series of AR-targeting microRNAs, among which miR-34c and miR-297 were found to regulate both AR and PlncRNA-1 expression at the post-transcriptional level. Together, the data generated in this study indicate that PlncRNA-1 sponges AR-targeting microRNAs to protect AR from microRNA-mediated down-regulation and that these events form a regulatory feed-forward loop in the development of PCa. |
| Pubmed ID | 26808578 |
| Year | 2016 |
| Title | A feed-forward regulatory loop between androgen receptor and PlncRNA-1 promotes prostate cancer progression. |
| External Links |
| Links for PlncRNA-1 | GenBank HGNC lncrnadb Noncode |
| Links for prostate cancer | Omim Cosmic |
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