Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

LncRNA centric

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   LncRNA Name POU5F1P1
   Synonyms POU5F1B, OCT4-PG1, OCT4PG1, OTF3C, OTF3P1, POU5F1P1, POU5F1P4, POU5FLC20, POU5FLC8
   Region GRCh38_8:127322183-127420066    Sequence
   Ensembl ENSG00000212993
   RefSeq NA
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name prostate cancer
   ICD-0-3 C61.9  
   Methods qPCR etc.
   Sample prostate cancer tissues
   Expression Pattern up-regulated
   Function Description

POU5F1P1 was found to be the only member of the POU5F1 family to be expressed in prostate with over-expression in prostatic carcinoma compared to surrounding prostatic tissue probably because of an increased density of expressing cells. The probability of a positive repeat biopsy increases with rising PCA3 scores. The PCA3 score was superior to %fPSA for predicting repeat prostate biopsy outcome and may be indicative of clinical stage and significance of pCa.

   Pubmed ID 20017164
   Year 2010
   Title POU5F1P1, a putative cancer susceptibility gene, is overexpressed in prostatic carcinoma.
   External Links
   Links for  POU5F1P1 GenBank       HGNC       lncrnadb       Noncode
   Links for  prostate cancer Omim       Cosmic

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