Detail
| LncRNA Name | PRAS |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR etc. |
| Sample | cell lines (SNU-C4R, SNU-C5R etc.) |
| Expression Pattern | down-regulated |
| Function Description | We selected three lncRNAs, snaR, BACE1AS, and PRAS, and we detected their expression by RT-qPCR using specific primer sets. SnaR and BACE1AS were significantly down-regulated in both resistant cell lines (SNU-C4R and SNU-C5R), whereas PRAS was down-regulated in SNU-C4R cells but not in SNU-C5R cells. Down-regulation of snaR decreased cell death after 5-FU treatment, which indicates that snaR loss decreases in vitro sensitivity to 5-FU. |
| Pubmed ID | 25078450 |
| Year | 2014 |
| Title | A long non-coding RNA snaR contributes to 5-fluorouracil resistance in human colon cancer cells. |
| External Links |
| Links for PRAS | GenBank HGNC lncrnadb Noncode |
| Links for colon cancer | Omim Cosmic |
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