Detail
| LncRNA Name | PRNCR1 |
| Synonyms | PRNCR1, CARLo-3, PCAT8 |
| Region | GRCh38_8:127079874-127092600 Sequence |
| Ensembl | ENSG00000282961 |
| RefSeq | NR_109833 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✔ |
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, RIP etc. |
| Sample | prostate cancer tissues, cell lines (LNCaP, LNCaP-cds1, LNCaP-cds2, CWR22Rv1 etc.) |
| Expression Pattern | up-regulated |
| Function Description | Here we report that two lncRNAs highly overexpressed in aggressive prostate cancer, PRNCR1 (also known as PCAT8) and PCGEM1, bind successively to the androgen receptor and strongly enhance both ligand-dependent and ligand-independent androgen-receptor-mediated gene activation programs and proliferation in prostate cancer cells. |
| Pubmed ID | 23945587 |
| Year | 2013 |
| Title | lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs. |
| External Links |
| Links for PRNCR1 | GenBank HGNC lncrnadb Noncode |
| Links for prostate cancer | Omim Cosmic |
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