Detail
| LncRNA Name | PTAF |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, etc. |
| Sample | ovarian cancer tissues, cell lines (SKOV3, A2780, OVCAR-3) |
| Expression Pattern | up-regulated |
| Function Description | we provided evidence that the lncRNA PTAF-miR-25-SNAI2 axis controlled EMT in OvCa. Our results revealed that up-regulated PTAF induced elevated SNAI2 expression by competitively binding to miR-25, which in turn promoted OvCa cell EMT and invasion.The mesenchymal OvCa patients in the TCGA dataset with high PTAF expression showed a poorer prognosis than those with low PTAF expression. we found that miR-25 not only had binding sites within SNAI2, a key TF regulating EMT, and PTAF but also had an inverse expression relationship with both SNAI2 and PTAF. |
| Pubmed ID | 29929545 |
| Year | 2018 |
| Title | Systematic analyses reveal long non-coding RNA (PTAF)-mediated promotion of EMT and invasion-metastasis in serous ovarian cancer. |
| External Links |
| Links for PTAF | GenBank HGNC lncrnadb Noncode |
| Links for ovarian cancer | Omim Cosmic |
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