Detail
| LncRNA Name | PTENP1 |
| Synonyms | PTENP1, PTEN-rs, PTEN2, PTENpg1, PTH2, psiPTEN |
| Region | GRCh38_9:33673504-33677499 Sequence |
| Ensembl | ENSG00000237984 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Cell transfection, Luciferase reporter assay, Cell migration and invasion assay etc. |
| Sample | gastric cancer tissues, cell lines (GES-1, AGS, SGC7901, MGC803 and BGC823) |
| Expression Pattern | down-regulated |
| Function Description | PTENP1 and PTEN were concurrently downregulated in GC samples. PTENP1 overexpression inhibited cell growth and induced apoptosis in GC cells. We further demonstrated that PTENP1 could act as a ceRNA to sponge miR-106b and miR-93 from targeting PTEN for downregulation using a novel ceRNA in vitro gradient assay. |
| Pubmed ID | 28212532 |
| Year | 2017 |
| Title | Long non-coding RNA PTENP1 functions as a ceRNA to modulate PTEN level by decoying miR-106b and miR-93 in gastric cancer. |
| External Links |
| Links for PTENP1 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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