Detail
| LncRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100, MIR1204HG |
| Region | GRCh38_8:127794533-128101253 Sequence |
| Ensembl | ENSG00000249859 |
| RefSeq | NR_003367 |
| Circulating | ✔ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | Intraductal Papillary Mucinous Neoplasms of the Pancreas |
| ICD-0-3 | C25 M8453/0 |
| Methods | qPCR etc. |
| Sample | blood |
| Expression Pattern | differential expression |
| Function Description | We hypothesized that circulating long non-coding RNAs (lncRNAs) may act as diagnostic markers of incidentally-detected cystic PDAC precursors known as intraductal papillary mucinous neoplasms (IPMNs) and predictors of their pathology/histological classification.PVT1 has been shown to be upregulated in PDAC tissues,to be correlated with clinical stage and poor survival,to be overexpressed in the saliva of PDAC cases versus healthy controls, and to contribute to susceptibility to PDAC as part of a genome-wide association study. |
| Pubmed ID | 28874676 |
| Year | 2017 |
| Title | Linc-ing Circulating Long Non-coding RNAs to the Diagnosis and Malignant Prediction of Intraductal Papillary Mucinous Neoplasms of the Pancreas. |
| External Links |
| Links for PVT1 | GenBank HGNC lncrnadb Noncode |
| Links for Intraductal Papillary Mucinous Neoplasms of the Pancreas | Omim Cosmic |
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