Detail
| LncRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100, MIR1204HG |
| Region | GRCh38_8:127794533-128101253 Sequence |
| Ensembl | ENSG00000249859 |
| RefSeq | NR_003367 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | bladder urothelial cancer |
| ICD-0-3 | M8120/3 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | cell lines (BUC, J82 and T24) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA PVT1 is overexpressed in multidrug resistant BUC tissues and cell lines, and PVT1 knockdown reduces BUC cell proliferation, invasiveness, and chemoresistance by modulating Wnt/B-catenin signaling. PVT1 was upregulated in BC, where it promoted tumor cell proliferation and suppressed apoptosis. |
| Pubmed ID | 28969069 |
| Year | 2017 |
| Title | LncRNA plasmacytoma variant translocation 1 is an oncogene in bladder urothelial carcinoma. |
| External Links |
| Links for PVT1 | GenBank HGNC lncrnadb Noncode |
| Links for bladder urothelial cancer | Omim Cosmic |
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