Detail
| LncRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100, MIR1204HG |
| Region | GRCh38_8:127794533-128101253 Sequence |
| Ensembl | ENSG00000249859 |
| RefSeq | NR_003367 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | esophageal squamous cell cancer |
| ICD-0-3 | |
| Methods | qPCR, Western blot, luciferase reporter assay |
| Sample | esophageal squamous cell carcinoma tissues, cell lines (KYSE30, KYSE410, KYSE520, KYSE510, KYSE140, and KYSE150) |
| Expression Pattern | up-regulated |
| Function Description | PVT1 expression is significantly up-regulated in ESCC tumor samples compared with their normal counterparts.PVT1 promote ESCC progression via functioning as a molecular sponge for miR-203 and LASP1 and provide the first evidence of dysregulated PVT1/miR-203/LASP1 axis in ESCC. |
| Pubmed ID | 28404954 |
| Year | 2017 |
| Title | Upregulation of the long non-coding RNA PVT1 promotes esophageal squamous cell carcinoma progression by acting as a molecular sponge of miR-203 and LASP1 |
| External Links |
| Links for PVT1 | GenBank HGNC lncrnadb Noncode |
| Links for esophageal squamous cell cancer | Omim Cosmic |
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