PVT1 affected cell proliferation, migration and in vitro vascular tube formation of HUVECs.In addition,it was determined that PVT1 was able to bind and degrade miR-26b to promote connective tissue growth factor (CTGF) and angiopoietin 2 (ANGPT2) expression.miR-26b was also identified to have a suppressive role in cell proliferation,migration and in vitro vascular tube formation of HUVECs via binding 3'-UTR regions and downregulating CTGF and ANGPT2 expression levels.PVT1 was important in angiogenesis of vascular endothelial cell as ceRNA to bind and degrade miR-26b,which expanded the current understanding of PVT1 as ceRNA to regulate biological processes.