Detail
| LncRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100, MIR1204HG |
| Region | GRCh38_8:127794533-128101253 Sequence |
| Ensembl | ENSG00000249859 |
| RefSeq | NR_003367 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | melanoma |
| ICD-0-3 | M8720/3 |
| Methods | qPCR, RIP etc. |
| Sample | cell line (A-375, sk-mel-5,PIG1), melanoma tissue |
| Expression Pattern | up-regulated |
| Function Description | PVT1 was highly expressed in the melanoma tissues and cells. Silencing of PVT1 significantly inhibited cell proliferation, migration and invasion, and arrested the cell cycle at the G0/G1 stage. Additionally, PVT1 silencing significantly decreased the cyclin D1 expression in the melanoma cells. |
| Pubmed ID | 29286144 |
| Year | 2017 |
| Title | Effect of long non-coding RNA PVT1 on cell proliferation and migration in melanoma. |
| External Links |
| Links for PVT1 | GenBank HGNC lncrnadb Noncode |
| Links for melanoma | Omim Cosmic |
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