Detail
| LncRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100, MIR1204HG |
| Region | GRCh38_8:127794533-128101253 Sequence |
| Ensembl | ENSG00000249859 |
| RefSeq | NR_003367 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 M8046/3 |
| Methods | qPCR, Luciferase reporter assay, RIP |
| Sample | cell lines (H1650, A549, H1975, and H358, BEAS-2B) |
| Expression Pattern | up-regulated |
| Function Description | PVT1 knockdown remarkably inhibited cell viability, invasion and promoted apoptosis in NSCLC cells.PVT1 could directly interact with miR-497.Moreover, PVT1 overexpression reversed the inhibitory effect of miR-497 on cell viability, invasion and promotion effect on apoptosis of NSCLC cells. knockdown of PVT1 inhibited tumor growth in vivo and promoted miR-497 expression.In human gastric cancer, PVT1 expression was found to serve as an independent predictor for overall survival. |
| Pubmed ID | 29133127 |
| Year | 2017 |
| Title | Knockdown of LncRNA PVT1 inhibits tumorigenesis in non-small-cell lung cancer by regulating miR-497 expression. |
| External Links |
| Links for PVT1 | GenBank HGNC lncrnadb Noncode |
| Links for non small cell lung cancer | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.