Detail
| LncRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100, MIR1204HG |
| Region | GRCh38_8:127794533-128101253 Sequence |
| Ensembl | ENSG00000249859 |
| RefSeq | NR_003367 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | RNAi, Microarray etc. |
| Sample | hepatocarcinoma tissue |
| Expression Pattern | down-regulated |
| Function Description | We speculated that PVT1 might play a significant role in HCC development and progression via regulation of various pathways and genes, especially DLC1 and the Hippo signaling pathway.Exploring the relationship between DLC1 expression and patient survival, we observed that high DLC1 expression correlated with better survival (51.45±3.93 months) compared to the low DLC1 expression group (45.42±4.23 months, P=0.253, Figure 9C) in HCC. More importantly, due to their wide distribution in the nucleus, lncRNAs can regulate the transcription of adjacent genes by combining the transcription factors or polymerases. |
| Pubmed ID | 28979669 |
| Year | 2017 |
| Title | Comprehensive analysis of long non-coding RNA PVT1 gene interaction regulatory network in hepatocellular carcinoma using gene microarray and bioinformatics |
| External Links |
| Links for PVT1 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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