he expression levels of both PVT1 and EZH2 were up-regulated in human glioma tissues and cell lines, and positively correlated with glioma malignancy.silencing of PVT1 expression resulted in decreased proliferation, increased apoptosis, and decreased migration and invasion.exogenous PVT1 led to increased EZH2 expression and increased proliferation and induced proliferation and invasion.long non-coding RNA PVT1 could be served as an indicator of glioma prognosis, and PVT1-EZH2 regulatory pathway may be a novel therapeutic target for treating glioma.high PVT1 expression levels correlated with patientsâ?? poor overall survival.