Detail
| LncRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100, MIR1204HG |
| Region | GRCh38_8:127794533-128101253 Sequence |
| Ensembl | ENSG00000249859 |
| RefSeq | NR_003367 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 M8046/3 |
| Methods | qPCR, Western blot |
| Sample | NSCLC tissues, cell lines (A549 and SPCA-1) |
| Expression Pattern | up-regulated |
| Function Description | PVT1 was overexpressed in the hypoxic lung cancer cells.PVT1 functioned as competing endogenous (ce)RNA for miR-199a-5p, upregulated expression of its endogenous targets HIF-1a and inhibited its function. |
| Pubmed ID | 29115513 |
| Year | 2017 |
| Title | LncRNA PVT1 regulate expression of HIF1a via functioning as ceRNA for miR-199a-5p in non-small cell lung cancer under hypoxia. |
| External Links |
| Links for PVT1 | GenBank HGNC lncrnadb Noncode |
| Links for non small cell lung cancer | Omim Cosmic |
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