Detail
| LncRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100, MIR1204HG |
| Region | GRCh38_8:127794533-128101253 Sequence |
| Ensembl | ENSG00000249859 |
| RefSeq | NR_003367 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | pancreatic ductal adenocarcinoma |
| ICD-0-3 | M9380/3 |
| Methods | qRT-PCR, Western blot assay, Luciferase reporter assay, RNA pull-down assay, RIP |
| Sample | PDA cell lines (HPAF-II, PANC-1, SW1990, BxPC-3, MIA PaCa-2, Capan-2 and AsPC-1)The immortalized pancreatic ductal epithelial cell line H6C7, The cell line (HEK 293 T), PDA specimens and adjacent non-tumor tissues |
| Expression Pattern | up-regulated |
| Function Description | PVT1 levels paralleled those of ULK1 protein in PDA cancer tissues. PVT1 promoted cyto-protective autophagy and cell growth by targeting ULK1 both in vitro and in vivo. Moreover, high PVT1 expression was associated with poor prognosis. Furthermore, we found that PVT1 acted as sponge to regulate miR-20a-5p and thus affected ULK1 expression and the development of pancreatic ductal adenocarcinoma. |
| Pubmed ID | 30001707 |
| Year | 2018 |
| Title | LncRNA PVT1 triggers Cyto-protective autophagy and promotes pancreatic ductal adenocarcinoma development via the miR-20a-5p/ULK1 Axis. |
| External Links |
| Links for PVT1 | GenBank HGNC lncrnadb Noncode |
| Links for pancreatic ductal adenocarcinoma | Omim Cosmic |
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