Detail
| LncRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100, MIR1204HG |
| Region | GRCh38_8:127794533-128101253 Sequence |
| Ensembl | ENSG00000249859 |
| RefSeq | NR_003367 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, etc. |
| Sample | Cancer tissues, 210 matched adjacent normal tissues. |
| Expression Pattern | up-regulated |
| Function Description | Our results suggest that high PVT1 expression might be a potential biomarker for assessing tumor recurrence and prognosis in colorectal cancer patients. PVT1 plays a role similar to the relevant proto-oncogene to promote the metastasis, proliferation, and invasion of malignant cells, and enhances the resistance of tumor cells to chemotherapeutic drugs. Kaplanā??Meier survival curve in CRC patients based on lncRNA PVT1 expression. Plasmacytoma variant translocation 1 (PVT1) transcripts are homologous to murine PVT1 genes and belong to the intergenic lncRNA. |
| Pubmed ID | 29888675 |
| Year | 2018 |
| Title | Long non-coding RNA PVT1 as a novel potential biomarker for predicting the prognosis of colorectal cancer. |
| External Links |
| Links for PVT1 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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