Detail
| LncRNA Name | PWRN1 |
| Synonyms | NA, NCRNA00198 |
| Region | GRCh38_15:24493137-24652130 Sequence |
| Ensembl | ENSG00000259905 |
| RefSeq | NR_026646 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Microarray, qPCR, Western blot,RIP, Luciferase reporter assay |
| Sample | cell line (HEK-293, GES-1, MGC-803, HGC-27, SGC-7901, MKN-45), GC tissues |
| Expression Pattern | up-regulated |
| Function Description | PWRN1 affected PTEN/Akt/MDM2/p53 axis via suppressing miR-425-5p.PWRN1 up-regulated could reduce proliferation and metastasis and increased apoptosis in GC cells, while miR-425-5p had reverse effects. PWRN1 may target an oncogene miR-425-5p. |
| Pubmed ID | 29535266 |
| Year | 2018 |
| Title | Prader-Willi region non-protein coding RNA 1 suppressed gastric cancer growth as a competing endogenous RNA of microRNA-425-5p. |
| External Links |
| Links for PWRN1 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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