Detail
| LncRNA Name | RAB11B-AS1 |
| Synonyms | NA |
| Region | GRCh38_19:8374373-8390685 Sequence |
| Ensembl | ENSG00000269386 |
| RefSeq | NR_038237 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | osteosarcoma |
| ICD-0-3 | M9180/3 |
| Methods | qPCR, Western blot, etc. |
| Sample | osteosarcoma tissues, cell lines (U2OS, Sao-2, MG-63, MNNG/HOS Cl#5[R-1059-D]) |
| Expression Pattern | down-regulated |
| Function Description | Here we discovered a novel lncRNA, RAB11B antisense RNA (RAB11B-AS1), which is markedly down-regulated in human osteosarcoma (OS) and associated with OS metastasis and poor prognosis. We find that reduction of RAB11B-AS1 significantly facilitates proliferation, migration and invasiveness and prevents apoptosis of OS cells and results in lower sensitivity to cisplatin in these cells.These data suggest that DNA hyper-methylation in the promoter region of lnc-RAB11B-AS1 might play an important role in down-regulation of lnc-RAB11B-AS1 in osteosarcoma. |
| Pubmed ID | 29928484 |
| Year | 2018 |
| Title | Long non-coding RNA RAB11B-AS1 prevents osteosarcoma development and progression via its natural antisense transcript RAB11B. |
| External Links |
| Links for RAB11B-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for osteosarcoma | Omim Cosmic |
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