Detail
| LncRNA Name | RGMB-AS1 |
| Synonyms | NA |
| Region | GRCh38_5:98769618-98773469 Sequence |
| Ensembl | ENSG00000246763 |
| RefSeq | NR_033932 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qRT-PCR, Western blot |
| Sample | hepatocellular carcinoma tissue, hepatocellular carcinoma cell lines (QGY-7703, HuH7, BEL-7402 and HepG2) |
| Expression Pattern | down-regulated |
| Function Description | lncRNA RGMB-AS1 was low-expressed in hepatocellular carcinoma tissues and cell lines, and associated with clinical stage, tumor size and metastasis. Survival analysis indicated that lncRNA RGMB-AS1 high was an independent favorable prognostic factor for hepatocellular carcinoma patients. Gain-of-function studies showed up-regulated lncRNA RGMB-AS1 expression suppressed hepatocellular carcinoma cells proliferation, migration and invasion, and promoted cells apoptosis. There was a positively association between lncRNA RGMB-AS1 and RGMB in hepatocellular carcinoma tissues, and up-regulated lncRNA RGMB-AS1 expression increased RGMB mRNA and protein expressions in hepatocellular carcinoma cells. |
| Pubmed ID | 29288973 |
| Year | 2017 |
| Title | The clinical significance and biological function of lncRNA RGMB-AS1 in hepatocellular carcinoma. |
| External Links |
| Links for RGMB-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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