Detail
| LncRNA Name | RNCR3 |
| Synonyms | LINC00599 |
| Region | GRCh38_8:9900064-9905366 Sequence |
| Ensembl | ENSG00000253230 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Luciferase reporter assay, Western blot, etc. |
| Sample | 52 pairs of prostate cancer tissue, adjacent normal prostate tissue. The prostate epithelial cell line (RWPE-1), human prostate cancer cell lines (LNCaP, DU145, PC-3). |
| Expression Pattern | up-regulated |
| Function Description | Our data revealed that RNCR3 functions as an tumor-promoting lncRNA in prostate cancer and may serve as a novel important biomarker for the diagnosis and treatment of prostate cancer. Upregulation of RNCR3 in prostate cancer cells compared with normal prostate epithelial cells RWPE-1. *P < 0.05. C. Kaplan-Meier survival curves for patients with prostate cancer tissues expressing low and high levels of RNCR3. We also confirmed that the oncogenic function of RNCR3 in prostate cancer are partly mediated by negative regulation of miR-185-5p targeted BRD8 ISO2. Moreover, knockdown of RNCR3 can also result to higher expression of IL-6, CCL2 and TNF-α in blood plasma, indicating that RNCR3 may have a biological function in immune system . |
| Pubmed ID | 29887969 |
| Year | 2018 |
| Title | Long non-coding RNA RNCR3 promotes prostate cancer progression through targeting miR-185-5p. |
| External Links |
| Links for RNCR3 | GenBank HGNC lncrnadb Noncode |
| Links for prostate cancer | Omim Cosmic |
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