Detail
| LncRNA Name | ROPNR |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | M9861/3 |
| Methods | qPCR, ChIP etc. |
| Sample | bone marrow, cell lines (KG-1, KG-1a, Kasumi-1, K562) |
| Expression Pattern | up-regulated |
| Function Description | We describe a RUNX1-intragenic long noncoding RNA ROPNR that is transcribed as unspliced transcript from an upstream overlapping promoter. ROPNR was upregulated in AML samples and in response to Ara-C treatment in vitro. ROPNR utilizes its 3'-terminal fragment to directly interact with the RUNX1 promoter and enhancers and participates in the orchestration of an intrachromosomal loop. The 3' region of ROPNR also participates in long-range interchromosomal interactions with chromatin regions that are involved in multiple RUNX1 translocations. |
| Pubmed ID | 24752773 |
| Year | 2014 |
| Title | An intragenic long noncoding RNA interacts epigenetically with the RUNX1 promoter and enhancer chromatin DNA in hematopoietic malignancies. |
| External Links |
| Links for ROPNR | GenBank HGNC lncrnadb Noncode |
| Links for acute myeloid leukemia | Omim Cosmic |
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