Detail
| LncRNA Name | RP11-137H2.4 |
| Synonyms | RP11-137H2.4, LOC101929574 |
| Region | GRCh38_10:80529597-80535942 Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✔ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | childhood acute lymphoblastic leukemia |
| ICD-0-3 | M9835/3 |
| Methods | qPCR, RNAi, Cell proliferation assay etc. |
| Sample | cell lines (Reh, NALM-6) |
| Expression Pattern | up-regulated |
| Function Description | Here we report five lncRNAs specifically upregulated in pre-B cALL that had significant impacts on cancer hallmark traits such as cell proliferation, migration, apoptosis, and treatment response. In particular, silencing of the RP11-137H2.4 lncRNA effectively restored normal glucocorticoid (GC) response in a GC-resistant pre-B cALL cell line and specifically modulated expression of members of both the NRAS/BRAF/NF-kB MAPK cascade and cell cycle pathways. |
| Pubmed ID | 27980230 |
| Year | 2017 |
| Title | A childhood acute lymphoblastic leukemia-specific lncRNA implicated in prednisolone resistance, cell proliferation, and migration. |
| External Links |
| Links for RP11-137H2.4 | GenBank HGNC lncrnadb Noncode |
| Links for childhood acute lymphoblastic leukemia | Omim Cosmic |
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