Detail
| LncRNA Name | RP11-169D4.1 |
| Synonyms | RP11-169D4.2, LINC01537 |
| Region | GRCh38_11:72570660-72573229 Sequence |
| Ensembl | ENSG00000227467 |
| RefSeq | NR_126364 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | laryngeal squamous cell cancer |
| ICD-0-3 | C32.3 |
| Methods | qPCR, Western blot etc. |
| Sample | laryngeal squamous cell carcinoma tissues, cell lines (SNU899 and SNU46) |
| Expression Pattern | down-regulated |
| Function Description | RP11-169D4.1 expression was markedly decreased in LSCC tissues and cell lines.The overexpression of RP11-169D4.1 inhibited the proliferation, migration and invasion of LSCC cell lines as well as promoted apoptosis.We further verified that miR-205-5p had binding sites with RP11-169D4.1 and that RP11-169D4.1 could regulate the expression of CDH1.Ectopic transfection of RP11-169D4.1 led to a significant reduction in the downstream signaling molecule AKT in LSCC cells. The long non-coding RNA RP11-169D4.1 may serve as a tumor suppressor and a promising therapeutic target in laryngeal cancer,which could inhibit the process of EMT by regulating CDH1. |
| Pubmed ID | 28534968 |
| Year | 2018 |
| Title | Functional significance of the long non-coding RNA RP11-169D4.1 as a metastasis suppressor in laryngeal squamous cell carcinoma by regulating CDH1. |
| External Links |
| Links for RP11-169D4.1 | GenBank HGNC lncrnadb Noncode |
| Links for laryngeal squamous cell cancer | Omim Cosmic |
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