Detail
LncRNA Name | RP11-708H21.4 |
Synonyms | NA |
Region | NA Sequence |
Ensembl | NA |
RefSeq | NA |
Circulating | ✘ |
Drug-resisitant | ✔ |
Prognostic | ✘ |
MiRNA | ✘ |
Variant | ✘ |
TF | ✘ |
Methylation | ✘ |
Cancer Name | colorectal cancer |
ICD-0-3 | C19.9 |
Methods | RNA-seq, qPCR, Western blot etc. |
Sample | colorectal cancer tissues, cell lines (DLD-1, SW-480, HT-29, SW-620, HCT-116 and LOVO) |
Expression Pattern | up-regulated |
Function Description | Overexpressed RP11-708H21.4 suppresses CRC cell proliferation through inducing G1 arrest. Moreover, up-regulation of RP11-708H21.4 inhibits cell migration and invasion, causes cell apoptosis, and enhances 5-FU sensitivity of CRC cells. |
Pubmed ID | 28427191 |
Year | 2017 |
Title | Down-regulation of long non-coding RNA RP11-708H21.4 is associated with poor prognosis for colorectal cancer and promotes tumorigenesis through regulating AKT/mTOR pathway |
External Links |
Links for RP11-708H21.4 | GenBank HGNC lncrnadb Noncode |
Links for colorectal cancer | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.