Detail
| LncRNA Name | RP11-789C1.1 |
| Synonyms | LINC01612 |
| Region | GRCh38_4:170273919-170283079 Sequence |
| Ensembl | ENSG00000250266 |
| RefSeq | NR_125889 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blot analysis, RNA pull-down assay, luciferase reporter assay |
| Sample | Human esophageal cancer cell lines (AGS, BGC-803, HGC-27, SGC-7901, MKN-1, MKN28, and MGC803), The normal human gastric epithelial cell line (GES-1), gastric cancer and adjacent normal tissues |
| Expression Pattern | down-regulated |
| Function Description | LncRNA RP11-789C1.1 was significantly down-regulated in GC patients and cell lines, along with the concomitant up-regulation of miR-5003. miR-5003 was the target of both RP11-789C1.1 and E-cadherin. Furthermore, at both the mRNA and protein level, silencing RP11-789C1.1 remarkably reduced the expression of E-cadherin and promoted EMT, which were reversed by knocking down miR-5003. |
| Pubmed ID | 29991048 |
| Year | 2018 |
| Title | Long Non-Coding RNA RP11-789C1.1 Suppresses Epithelial to Mesenchymal Transition in Gastric Cancer Through the RP11-789C1.1/MiR-5003/E-Cadherin Axis. |
| External Links |
| Links for RP11-789C1.1 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.