Detail
| LncRNA Name | RP11-838N2.4 |
| Synonyms | NA |
| Region | GRCh38_18:3466250-3478978 Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioblastoma |
| ICD-0-3 | M9440/3 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | glioblastoma tissues, cell lines (U87, U251) |
| Expression Pattern | down-regulated |
| Function Description | We found that the level of the lncRNA RP11-838N2.4 was lower in TMZ-resistant GBM cells (U87TR, U251TR) compared to the parental, non-resistant GBM cells (U87, U251).In GBM patients, the decreased level of lncRNA RP11-838N2.4 correlated with higher risk of GBM relapse, as well as shorter postoperative survival times.Moreover, lncRNA RP11-838N2.4 acts as an endogenous sponge, suppressing the function of miR-10a through conserved sequences and increasing the expression of EphA8 that enhanced the rate of cell apoptosis, thereby intensified sensitivity of GBM cells to TMZ |
| Pubmed ID | 27270310 |
| Year | 2016 |
| Title | Long noncoding RNA RP11-838N2.4 enhances the cytotoxic effects of temozolomide by inhibiting the functions of miR-10a in glioblastoma cell lines |
| External Links |
| Links for RP11-838N2.4 | GenBank HGNC lncrnadb Noncode |
| Links for glioblastoma | Omim Cosmic |
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